Central muscle relaxant effects of diazepam
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چکیده
منابع مشابه
Central muscle relaxant effects of diazepam.
Motor depressant effects of diazepam were studied in the intact, decerebrate and high spinal cat. Diazepam (0.125516 mg/kg, i.v.) produced a depression of both the patellar and linguomandibular reflexes in the intact cat. In the high spinal (Cl) cat only the linguomandibular reflex was depressed. Facilitation and inhibition of the patellar reflex elicited in both intact and high spinal (Cl) cat...
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The mechanisms by which benzodiazepines produce muscle relaxation and respiratory depression are not known, but they may include actions on peripheral benzodiazepine receptors or central GABA receptors, or a direct action on airway smooth muscle may also be involved. We have compared, therefore, the effects of diazepam, flunitrazepam and midazolam on airway tone by measuring isometric tension o...
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The effect of pancuronium bromide (0.025 mg/kg. B.W.) alone or combined with diazepam (1mg/Kg. I.V) were evaluated in six adult ewes. Pancuronium bromide alone exhibited a muscle relaxants effect, but without analgesia. All baseline measurements were taken before the administration the anesthetic agent and were repeated at 5,10,15,20 and 25 min. intervals after induction an aesthesia alone or c...
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Diazepam (Valium) was given to 13 patients during nitrous oxide, oxygen and halothane anaesthesia. Abdominal relaxation was not regularly produced and the amount of tubocurarine required subsequently to produce relaxation was the same as required in patients who had not had diazepam. The drug produced central respiratory depression affecting tidal volume only. It tended to lower the blood press...
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BACKGROUND Carbenoxolone, as an antiulcer medicine, has some pharmacological properties such as: the inhibition of gap junctional (GJ) intercellular communication. In vitro studies have shown, carbenoxolone to abolish the generation of full or partial ectopic spike generation, by 4-aminopyridine, as well as spontaneous epileptiform activity in CA3 or CA1 regions of the rat hippocampal slices vi...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 1970
ISSN: 0028-3908
DOI: 10.1016/0028-3908(70)90021-3